Antitumor Activity of Asymmetric Schiff-Base Complexes of Cobalt(II) and Nickel(II)

Document Type : Original Article


1 Department of Chemistry, Faculty of Science, Ilam University, Ilam, Iran

2 Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran



A new bidentate Schiff-base ligand derived from 4-nitro-o-phenylenediamine and 3-phenylpropenal and its complexes with Co(II) and Ni(II) metal ions have been synthesized. Various methods like thermogravimetric analysis (TGA), nuclear magnetic resonance (1H- and 13C-NMR), molar conductance, furrier transform infrared (FT-IR) and Ultraviolet–Visible (UV-Vis) spectroscopies are applied for characterization of Schiff-base ligand and its complexes. Based elemental analysis data the MLX2 [M=Co(II) and Ni(II); X=Cl, Br and L=N,N'–bis((E)-3–phenylallylidene)-4-nitro-1,2-phenylenediamine] formula is supposed for these metal complexes. Low molar conductivities in DMF confirm their non-electrolytic nature of them, just in the case of NiLBr2 the slight electrolyte character might be observed. Other evidences that confirmed the formation of Schiff-base complexes are changes in the location and shape of the peaks in UV-Vis and FT-IR spectra of complexes with respect to free ligand and distorted-tetrahedral structure is suggested for metal complexes. Anticancer activities of these complexes against A549 cancer cell line demonstrated these complexes are excellent candidates in the biological systems.


Main Subjects

Articles in Press, Accepted Manuscript
Available Online from 12 May 2021
  • Receive Date: 09 October 2020
  • Revise Date: 27 September 2021
  • Accept Date: 30 April 2021