Iodine-promoted oxidative cyclization for green synthesis of 2-arylquinazolin-4(3H)-ones in polyethylene glycol (PEG)

Document Type: Original Article

Authors

1 CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran

2 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Abstract

A metal-free and iodine promoted oxidative system for cyclization of primary benzyl amines with anthranilamide to afford 2-arylquinazolin-4(3H)-ones in PEG-400 as a green, inexpensive, non-toxic and reusable solvent medium has been developed.

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Main Subjects


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